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Papers of the Week


Papers: 12 Aug 2023 - 18 Aug 2023

RESEARCH TYPE:
Review


Molecular/Cellular, Neurobiology

PAIN TYPE:
Inflammation/Inflammatory, Itch


2023 Aug 11


Neuroscience


37574108

IL-33/ST2 signaling in the pathogenesis of chronic pain and itch.

Authors

Gao TC, Wang CH, Wang YQ, Mi WL

Abstract

Interleukin-33 (IL-33) is an inflammatory factor with an extensive range of biological effects and pleiotropic roles in diseases. Evidence suggests that IL-33 and its receptor ST2 play a pivotal role in chronic pain and itch at the level of primary sensory neurons, the spinal cord, and the brain. In this review, we outline an evolving understanding of the roles and mechanisms of interleukin-33 in chronic pathological pain, including inflammatory, neuropathic, and cancer, and chronic pruritus, such as allergic contact dermatitis, atopic dermatitis, and dry skin. Understanding the key roles of IL-33/ST2 signaling may provide exciting insights into the mechanisms of chronic pain and itch and lead to new clues for therapeutic approaches to the resolution of chronic pain and itch.