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Papers of the Week

Papers: 18 Nov 2023 - 24 Nov 2023

2023 Nov 18

J Allergy Clin Immunol


IL-33 Potentiates Histaminergic Itch.


Trier AM, Heul AV, Fredman A, Le V, Wang Z, Auyeung K, Meixiong J, Lovato P, Holtzman MJ, Wang F, Dong X, Ji AL, Kim BS


Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU), many patients remain symptomatic on maximal doses. Mechanisms that drive resistance to antihistamines are poorly defined.