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Papers of the Week
IL-33 Potentiates Histaminergic Itch.
Authors
Trier AM, Heul AV, Fredman A, Le V, Wang Z, Auyeung K, Meixiong J, Lovato P, Holtzman MJ, Wang F, Dong X, Ji AL, Kim BSAbstract
Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU), many patients remain symptomatic on maximal doses. Mechanisms that drive resistance to antihistamines are poorly defined.