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Papers of the Week

Papers: 1 Jun 2024 - 7 Jun 2024

2024 Jun 04

Osteoarthritis Cartilage


IL-23p19 in osteoarthritic pain and disease.


Lee KM, Lupancu T, Achuthan AA, de Steiger R, Hamilton JA


We have previously reported that the interleukin-23 p19 subunit (IL-23p19) is required for experimental inflammatory arthritic pain-like behaviour and disease. Even though inflammation is often a characteristic feature of osteoarthritis (OA), IL-23 is not usually considered as a therapeutic target in OA. We began to explore the role of IL-23p19 in OA pain and disease utilizing mouse models of OA and patient samples.