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Papers of the Week
Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis.
Authors
Sarsenova M, Boggavarapu NR, Kask K, Modhukur V, Samuel K, Karro H, Gemzell-Danielsson K, Lalitkumar PGL, Salumets A, Peters M, Lavogina DAbstract
Endometriosis is characterized by the ectopic growth of endometrial-like cells, causing chronic pelvic pain, adhesions and impaired fertility in women of reproductive age. Usually, these lesions grow in the peritoneal cavity in a hypoxic environment. Hypoxia is known to affect gene expression and protein kinase (PK) activity. We aimed to explore the changes in the transcriptome and PK activity characteristic of eutopic and ectopic endometrium in endometriosis under hypoxia.