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Papers of the Week
Hypersensitivity to BK channel opening in persistent post-traumatic headache.
Authors
Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Melchior AG, Burstein R, Ashina HAbstract
Large conductance calcium-activated potassium (BK) channels have been implicated in the neurobiological underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to examine whether MaxiPost (a BK channel opener) could induce migraine-like headache in persons with PPTH.