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Papers of the Week

Papers: 30 Sep 2023 - 6 Oct 2023

2023 Oct 05



How can experimental endotoxemia contribute to our understanding of pain? A narrative review.


Benson S, Karshikoff B


The immune system and the central nervous system exchange information continuously. This communication is a prerequisite for adaptive responses to physiological and psychological stressors. While the implicate relationship between inflammation and pain is increasingly recognized in clinical cohorts, the underlying mechanisms and the possibilities for pharmacological and psychological approaches aimed at neuro-immune communication in pain are not fully understood yet. This calls for preclinical models which build a bridge from clinical research to laboratory research.