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Papers of the Week

Papers: 20 Apr 2024 - 26 Apr 2024

2024 Jun

Pain Rep




Hippocampus diffusivity abnormalities in classical trigeminal neuralgia.


Hanycz SA, Noorani A, Hung PS, Walker MR, Zhang AB, Latypov TH, Hodaie M


Patients with chronic pain frequently report cognitive symptoms that affect memory and attention, which are functions attributed to the hippocampus. Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by paroxysmal attacks of unilateral orofacial pain. Given the stereotypical nature of TN pain and lack of negative symptoms including sensory loss, TN provides a unique model to investigate the hippocampal implications of chronic pain. Recent evidence demonstrated that TN is associated with macrostructural hippocampal abnormalities indicated by reduced subfield volumes; however, there is a paucity in our understanding of hippocampal microstructural abnormalities associated with TN.