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Papers of the Week


Papers: 12 Oct 2024 - 18 Oct 2024


2024


Front Pharmacol


39411061


15

Hemoglobin α-derived peptides VD-hemopressin (α) and RVD-hemopressin (α) are involved in electroacupuncture inhibition of chronic pain.

Authors

Yuan X, Guo Y, Yi H, Hou X, Zhao Y, Wang Y, Jia H, Baba SS, Li M, Huo F

Abstract

Knee osteoarthritis (KOA) is a chronic degenerative bone metabolic disease that primarily affects older adults, leading to chronic pain and disability that affect patients’ daily activities. Electroacupuncture (EA) is a commonly used method for the treatment of chronic pain in clinical practice. Previous studies indicate that the endocannabinoid system is involved in EA analgesia, but whether endocannabinopeptide VD-hemopressin (α) and RVD-hemopressin (α) derived from hemoglobin chains are involved in EA analgesia is unclear.