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Papers of the Week

Papers: 16 Dec 2023 - 22 Dec 2023

2023 Dec

Pain Rep




Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia.


Ostertag C, Friedman TN, Keough MB, Kerr BJ, Sankar T


Trigeminal neuralgia (TN) is a chronic, debilitating facial pain disease causing stabbing pain attacks in the sensory distribution of the trigeminal nerve. The underlying pathophysiology of TN is incompletely understood, although microstructural abnormalities consistent with focal demyelination of the trigeminal nerve root have been shown in patients with TN. Studies of the cerebrospinal fluid (CSF) in patients with TN suggest an increased prevalence of inflammatory mediators, potentially implicating neuroinflammation in the pathophysiology of TN, as it has been implicated in other chronic pain conditions.