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Papers of the Week


Papers: 29 Jun 2024 - 5 Jul 2024


2024 Jul


CNS Neurosci Ther


38961317


30


7

HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.

Authors

Cao XZ, Zhu MY, Xu G, Li F, Yan Y, Zhang JJ, Wang J, Zeng F, Bao Y, Zhang XX, Liu T, Zhang DY

Abstract

Comorbid anxiodepressive-like symptoms (CADS) in chronic pain are closely related to the overactivation of the lateral habenula (LHb). Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated to play a key role in regulating neuronal excitability. However, the role of HCN channels in the LHb during CADS has not yet been characterized. This study aimed to investigate the effect of HCN channels in the LHb on CADS during chronic pain.