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Papers of the Week

Papers: 29 Jun 2024 - 5 Jul 2024

2024 Jul

CNS Neurosci Ther




HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.


Cao XZ, Zhu MY, Xu G, Li F, Yan Y, Zhang JJ, Wang J, Zeng F, Bao Y, Zhang XX, Liu T, Zhang DY


Comorbid anxiodepressive-like symptoms (CADS) in chronic pain are closely related to the overactivation of the lateral habenula (LHb). Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated to play a key role in regulating neuronal excitability. However, the role of HCN channels in the LHb during CADS has not yet been characterized. This study aimed to investigate the effect of HCN channels in the LHb on CADS during chronic pain.