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Papers of the Week


Papers: 12 Oct 2024 - 18 Oct 2024


2024 Dec


JOR Spine


39398942


7


4

Gut microbiome dysbiosis is associated with lumbar degenerative spondylolisthesis in symptomatic patients.

Authors

Aboushaala K, Chee AV, Adnan D, Toro SJ, Singh H, Savoia A, Dhillon ES, Yuh C, Dourdourekas J, Patel IK, Vucicevic R, Espinoza-Orias AA, Martin JT, Oh C, Keshavarzian A, Albert HB, Karppinen J, Kocak M, Wong AYL, Goldberg EJ, Phillips FM, Colman MW, Williams FMK, Borgia JA, Naqib A, Green SJ, Forsyth CB, An HS, Samartzis D

Abstract

Lumbar degenerative spondylolisthesis (LDS), characterized as degeneration of the intervertebral disc and structural changes of the facet joints, is a condition with varying degrees of instability that may lead to pain, canal stenosis, and subsequent surgical intervention. However, the etiology of LDS remains inconclusive. Gut microbiome dysbiosis may stimulate systemic inflammation in various disorders. However, the role of such dysbiosis upon spine health remains under-studied. The current study assessed the association of gut microbiome dysbiosis in symptomatic patients with or without LDS.