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Papers: 18 Mar 2023 - 24 Mar 2023
RESEARCH TYPE:
Clinical
Genetics, Human Studies
PAIN TYPE:
Cancer Pain, Neuropathic Pain
2023 Mar 20
J Cancer Res Clin Oncol
Chemotherapy induced peripheral neuropathy (CIPN) is a debilitating condition that is a direct consequence of receiving cancer treatment. The molecular aetiology of CIPN is not well understood, and it is theorised that there may be a genetic component. Genetic polymorphisms in Glutathione-S Transferase (GST) genes, including GSTT1, GSTM1 and GSTP1, encode for enzymes known to metabolise drugs used in chemotherapy, and have been theorised to be associated with CIPN. This study aimed to investigate four markers in these genes for an association in a mixed cancer cohort in relation to CIPN (n = 172).