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Papers of the Week

Papers: 4 May 2024 - 10 May 2024

2024 May 08

Mol Pain


Grape seed-derived procyanidins decreases neuropathic pain and nerve regeneration by suppression of TLR4-Myd88 signaling.


Hu L, An E, Zhu Z, Cai Y, Ye X, Zhou H, Ge H


Recent studies have shown that peripheral nerve regeneration process is closely related to neuropathic pain. Toll-like receptor 4 (TLR4) signaling was involved in different types of pain and nerve regeneration. TLR4 induced the recruitment of myeloid differentiation factor-88 adaptor protein (MyD88) and NF-κB-depended transcriptional process in sensory neurons and glial cells, which produced multiple cytokines and promoted the induction and persistence of pain. Our study aimed to investigate procyanidins’s effect on pain and nerve regeneration via TLR4-Myd88 signaling.