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Papers of the Week
Glucocorticoid nanoformulations relieve chronic pelvic pain syndrome and may alleviate depression in mice.
Authors
Yang Y, Hu R, Zheng J, Wang Q, Xu S, Zhou Z, Zhang D, Shen WAbstract
Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis (CP) in males that may cause abnormal urination, sexual dysfunction, or depression and significantly affect the quality of life of the patient. Currently, there is no effective treatment for CPPS due to its recurrence and intractability. For synergistic CPPS therapy, we developed pH/reactive oxygen species (ROS) dual-responsive dexamethasone (Dex) nanoformulations using a ROS-responsive moiety and phytochemical modified α-cyclodextrin (α-CD) as the carrier.