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Papers of the Week

Papers: 2 Sep 2023 - 8 Sep 2023

Basic Science

Genetics, Human Studies, Neurobiology, Pharmacology/Drug Development

2023 Sep 05

Biol Psychiatry


Genetically-regulated gene expression in the brain associated with chronic pain: relationships with clinical traits and potential for drug repurposing.


Johnston KJ, Cote AC, Hicks E, Johnson J, Huckins LM


Chronic pain is a common, poorly-understood condition. Genetic studies including genome wide association studies (GWAS) identify many relevant variants, which have yet to be translated into full understanding of chronic pain. Transcriptome wide association study using transcriptomic imputation (TI) methods such as S-PrediXcan can help bridge this genotype-phenotype gap.