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Papers of the Week

Papers: 29 Jun 2024 - 5 Jul 2024

2024 Jul 02



Genetically predicted immune cells mediate the association between gut microbiota and neuropathy pain.


Lan Z, Wei Y, Yue K, He R, Jiang Z


Previous observational studies have indicated a complex association between gut microbiota (GM) and neuropathic pain (NP). Nonetheless, the precise biological mechanisms underlying this association remain unclear. Therefore, we adopted a Mendelian randomization (MR) approach to investigate the causal relationship between GM and neuropathic pain including post-herpetic neuralgia (PHN), painful diabetic peripheral neuropathy (PDPN), and trigeminal neuralgia (TN), as well as to explore the potential mediation effects of immune cells.