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Papers of the Week
Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain.
Authors
Farrell SF, Sterling M, Klyne DM, Mustafa S, Campos AI, Kho PF, Lundberg M, Rentería ME, Ngo TT, Cuéllar-Partida GAbstract
Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & widespread pain can be explained by shared underlying genetic variants; and (ii) higher CRP levels causally contribute to these conditions.