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Papers of the Week


Papers: 15 Apr 2023 - 21 Apr 2023

RESEARCH TYPE:
Translational


Genetics, Human Studies, Molecular/Cellular, Neurobiology

PAIN TYPE:
Musculoskeletal Pain, Orofacial/Head Pain


2023 Apr 17


Eur Spine J


37069442

Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain.

Authors

Farrell SF, Sterling M, Klyne DM, Mustafa S, Campos AI, Kho PF, Lundberg M, Rentería ME, Ngo TT, Cuéllar-Partida G

Abstract

Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & widespread pain can be explained by shared underlying genetic variants; and (ii) higher CRP levels causally contribute to these conditions.