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Papers of the Week

Papers: 1 Jun 2024 - 7 Jun 2024

2024 Jun 05

J Headache Pain




Genetic evidence for the causal relationships between migraine, dementia, and longitudinal brain atrophy.


Zhao L, Tang Y, Tu Y, Cao J


Migraine is a neurological disease with a significant genetic component and is characterized by recurrent and prolonged episodes of headache. Previous epidemiological studies have reported a higher risk of dementia in migraine patients. Neuroimaging studies have also shown structural brain atrophy in regions that are common to migraine and dementia. However, these studies are observational and cannot establish causality. The present study aims to explore the genetic causal relationship between migraine and dementia, as well as the mediation roles of brain structural changes in this association using Mendelian randomization (MR).