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Papers of the Week

Papers: 5 Aug 2023 - 11 Aug 2023

Basic Science

Genetics, Human Studies, Neurobiology, Neuroimaging

Neuropathic Pain

2023 Aug 09

J Peripher Nerv Syst


Genetic, Electrophysiological, and Pathological Studies on Patients with SCN9A-related Pain Disorders.


Yuan JH, Cheng X, Matsuura E, Higuchi Y, Masahiro A, Hashiguchi A, Yoshimura A, Nakachi R, Mine J, Taketani T, Maeda K, Kawakami S, Kira R, Tanaka S, Kanai K, Dib-Hajj F, Dib-Hajj SD, Waxman SG, Takashima H


Voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, has been linked to diverse painful peripheral neuropathies, represented by the inherited erythromelalgia (EM) and paroxysmal extreme pain disorder (PEPD). The aim of this study was to determine the genetic etiology of patients experiencing neuropathic pain, and shed light on the underlying pathogenesis.