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Papers of the Week

Papers: 10 Jun 2023 - 16 Jun 2023

Clinical, Methodology

Human Studies, Pharmacology/Drug Development, Sex Differences


2023 Jun 14

Acta Anaesthesiol Scand


Generalizability of nociception level as a measure of intraoperative nociceptive stimulation: A retrospective analysis.


Ruetzler K, Montalvo M, Rotem OM, Ekrami E, Rössler J, Duran JAA, Dahan A, Gozal Y, Richebe P, Farhang B, Turan A, Sessler DI


Nociception-guided intraoperative opioid administration might help reduce postoperative pain. A commonly used and validated nociception monitor system is nociception level (NOL), which provides the nociception index, ranging from 0 to 100, with 0 representing no nociception and 100 representing extreme nociception. We tested the hypothesis that NOL responses are similar in men and women given remifentanil and fentanyl, across various types of anesthesia, as a function of American Society of Anesthesiologists physical status designations, and over a range of ages and body morphologies.