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Papers of the Week

Papers: 1 Jun 2024 - 7 Jun 2024

2024 May 31

Eur J Pain


Gastrointestinal pain: A systematic review of temporal summation of pain paradigms and outcomes.


Huisman D, Mansfield M, Cummins TM, Moss-Morris R, McMahon SB, Bannister K


Since targeted treatment for gastrointestinal pain is elusive, identifying the mechanistic underpinning of this pain type is important. Facilitation of spinal neuronal responses underpins certain pain types, and the psychophysical temporal summation of pain (TSP) paradigm provides a proxy measure of spinal facilitatory processes. Our aim was to systematically review whether facilitated TSP is a feature of gastrointestinal pain in patients with, or pain-free people experiencing experimentally induced, gastrointestinal pain.