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Papers of the Week

Papers: 18 Feb 2023 - 24 Feb 2023


Animal Studies, Neurobiology, Neuromodulation

Acute Pain

2023 Feb 23

Reg Anesth Pain Med


Focused ultrasound-induced inhibition of peripheral nerve fibers in an animal model of acute pain.


Anderson TA, Pacharinsak C, Vilches-Moure J, Kantarci H, Zuchero JB, Butts-Pauly K, Yeomans D


Moderate-to-severe acute pain is prevalent in many healthcare settings and associated with adverse outcomes. Peripheral nerve blockade using traditional needle-based and local anesthetic-based techniques improves pain outcomes for some patient populations but has shortcomings limiting use. These limitations include its invasiveness, potential for local anesthetic systemic toxicity, risk of infection with an indwelling catheter, and relatively short duration of blockade compared with the period of pain after major injuries. Focused ultrasound is capable of inhibiting the peripheral nervous system and has potential as a pain management tool. However, investigations of its effect on peripheral nerve nociceptive fibers in animal models of acute pain are lacking. In an in vivo acute pain model, we investigated focused ultrasound’s effects on behavior and peripheral nerve structure.