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Papers of the Week

Papers: 3 Feb 2024 - 9 Feb 2024

2024 Feb 06

Eur J Pain


Familial effects account for association between chronic pain and past month smoking.


Rader L, Reineberg AE, Petre B, Wager TD, Friedman NP


Smoking is associated with chronic pain, but it is not established whether smoking causes pain or if the link is due to familial effects. One proposed mechanism is that smoking strengthens maladaptive cortico-striatal connectivity, which contributes to pain chronification. We leveraged a twin design to assess direct effects of smoking on pain controlling for familial confounds, and whether cortico-striatal connectivity mediates this association.