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Papers of the Week

Papers: 4 May 2024 - 10 May 2024

2024 May 10

J Headache Pain




Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats.


Alpay B, Cimen B, Akaydin E, Onat F, Bolay H, Sara Y


GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors. The role of extrasynaptic GABAergic input in migraine is unknown. We investigated the susceptibility to valid migraine-provoking substances with clinically relevant behavioral readouts in Genetic Absence Epilepsy of Rats Strasbourg (GAERS), in which the GABAergic tonus was altered. Subsequently, we screened relevant GABAergic mechanisms in Wistar rats by pharmacological means to identify the mechanisms.