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Papers of the Week


Papers: 5 Oct 2024 - 11 Oct 2024


2024 Oct 07


J Neuroinflammation


39375720


21


1

Extracellular vesicles in sepsis plasma mediate neuronal inflammation in the brain through miRNAs and innate immune signaling.

Authors

Park C, Lei Z, Li Y, Ren B, He J, Huang H, Chen F, Li H, Brunner K, Zhu J, Jay SM, Williams B, Chao W, Wu J, Zou L

Abstract

Neuroinflammation reportedly plays a critical role in the pathogenesis of sepsis-associated encephalopathy (SAE). We previously reported that circulating plasma extracellular vesicles (EVs) from septic mice are proinflammatory. In the current study, we tested the role of sepsis plasma EVs in neuroinflammation.