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Papers of the Week
Exoticin as a selective agonist of 6TM μ opioid receptors identifies endogenous chaperones essential for its activity.
Authors
Qin F, Wang Q, Wang Y, Li Z, Liu A, Liu Q, Lin W, Mu X, Liu X, Wang Q, Lu ZAbstract
Classical opioids are effective analgesics but carry various side effects, necessitating safer alternatives. Truncated six-transmembrane mu opioid receptors (6TM-μORs) mediate potent analgesia with fewer side effects and are a promising therapeutic target. However, few ligands known selectively target 6TM-μORs. Moreover, endogenous chaperones are believed essential for 6TM-μOR ligand binding and function.