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Papers of the Week
Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case-control study.
Authors
Wiemann M, Zimowski N, Blendow SL, Enax-Krumova E, Naegel S, Fleischmann R, Strauss SAbstract
Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.