I am a
Home I AM A Search Login

Papers of the Week


Papers: 23 Nov 2024 - 29 Nov 2024


2024 Nov 25


Eur J Pain


39584590

Evaluating multiplicity reporting in analgesic clinical trials: An analytical review.

Authors

Khan MS, Zarmer LF, Liang J, Saroukhani S, Lucas AR, McCartney CJL, Chaudhry R

Abstract

Analgesia trials often demands multiple comparisons to assess various treatment arms, outcomes, or repeated assessments. These multiple comparisons risk inflating the false positive rate. Multiplicity correction in recent analgesic randomized controlled trials (RCTs) remains unclear despite statistical method advancements and regulatory guidelines. Our study aimed to identify reporting inadequacies in multiple analysis adjustments and explanations to understand these deficiencies.