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Papers of the Week

Papers: 29 Apr 2023 - 5 May 2023

Basic Science

In Vitro Studies, Molecular/Cellular, Pharmacology/Drug Development

Arthritis, Musculoskeletal Pain

2023 Apr 28

Mol Biol Rep


Enhancement of mesenchymal stem cells’ chondrogenic potential by type II collagen-based bioscaffolds.


Piperigkou Z, Bainantzou D, Makri N, Papachristou E, Mantsou A, Choli-Papadopoulou T, Theocharis AD, Karamanos NK


Osteoarthritis (OA) is a common degenerative chronic disease accounting for physical pain, tissue stiffness and mobility restriction. Current therapeutic approaches fail to prevent the progression of the disease considering the limited knowledge on OA pathobiology. During OA progression, the extracellular matrix (ECM) of the cartilage is aberrantly remodeled by chondrocytes. Chondrocytes, being the main cell population of the cartilage, participate in cartilage regeneration process. To this end, modern tissue engineering strategies involve the recruitment of mesenchymal stem cells (MSCs) due to their regenerative capacity as to promote chondrocyte self-regeneration.