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Papers of the Week

Papers: 9 Mar 2024 - 15 Mar 2024

2024 Mar 12

Mil Med Res




Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking.


Xie MX, Lai RC, Xiao YB, Zhang X, Cao XY, Tian XY, Chen AN, Chen ZY, Cao Y, Li X, Zhang XL


Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is documented in the endocytosis pathway. However, the role of EndoA2 in the regulation of mechanical sensitivity and its underlying mechanisms are currently unclear.