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Papers of the Week
Endogenous cholinergic system involved in peripheral analgesic control in mice is activated by TNF-α, CXCL-1 and IL-1 β.
Authors
Gonzaga ACR, Quintão JLD, Galdino G, Romero TRL, Silva GCD, Lemos VS, Campolina-Silva GH, Oliveira CA, Mahecha GAB, Duarte IDGAbstract
Tissue injury results in the release of inflammatory mediators, including a cascade of algogenic substances, which contribute to the development of hyperalgesia. During this process, endogenous analgesic substances are peripherally released to counterbalance hyperalgesia. The present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE) and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the cholinergic system.