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Papers of the Week
Electrophysiological characteristics of neuropathic pain model in mice and a technique to evaluate peripheral nerve damage in the sciatic nerve.
Authors
Suzuki H, Funaba M, Ogi S, Matsumoto K, Nishida N, Fujimoto K, Sakai T, Nishikawa KAbstract
Experimental neuropathic pain (NP) models were developed from peripheral injuries and are widely used for pain research. However, previously published methods and outcomes in the evaluation of sciatic nerve dysfunction vary widely across each report. In this study, we established the electrophysiological analysis of sensory nerve action potentials (SNAPs) and compound motor action potentials (CMAPs) as objective methods for evaluating sciatic nerve dysfunction and revealed the electrophysiological characteristics of NP mice models.