I am a
Home I AM A Search Login

Papers of the Week

Papers: 11 May 2024 - 17 May 2024

2024 May 14

Mol Pain


Electroacupuncture improves allodynia and central sensitization via modulation of microglial activation associated P2X4R and inflammation in a rat model of migraine.


Zhou M, Pang F, Liao D, Yang Y, Wang Y, Yang Z, He X, Tang C


Recent studies have demonstrated that activated microglia were involved in the pathogenesis of central sensitization characterized by cutaneous allodynia in migraine.Activation of microglia is accompanied by increased expression of its receptors and release of inflammatory mediators.Acupuncture and its developed electroacupuncture (EA) have been recommended as an alternative therapy for migraine and are widely used for relieving migraine-associated pain.However,it remains rare studies that show whether EA exerts anti-migraine effects via inhibiting microglial activation related to a release of microglial receptors and the inflammatory pathway.Therefore,this study aimed to investigate EA’ ability to ameliorate central sensitization via modulation of microglial activation,microglial receptor,and inflammatory response using a rat model of migraine induced by repeated epidural chemical stimulation.