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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2024 Dec 31


Transl Pediatr


39823012


13


12

Efficacy of prophylactic sodium valproate in pediatric migraines: a systematic review of randomized clinical studies.

Authors

Askar G, Askar O, Altuhafy M, Nagi R, Khan J

Abstract

Migraine is a neurological disorder that is chronic and presents with episodes of paroxysmal features consisting of multiphase attacks of head pain, along with other symptoms related to neurological dysfunction such as sensitivity to movement, photophobia, phonophobia, nausea, and vomiting. Antiseizure medications are frequently used for the treatment of migraine. Of the antiseizure medications, sodium valproate and topiramate have received approval from the Food and Drug Administration (FDA) to prevent adult migraine. More recently, topiramate gained approval for pediatric migraine, whereas sodium valproate did not. Nevertheless, the off-label utilization of these drugs for pediatric migraine is widespread. The objective of this review is to assess the prophylactic efficacy of sodium valproate in the management of pediatric migraines.