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Papers of the Week


Papers: 13 May 2023 - 19 May 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Neurobiology, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2023 May


Headache


37183526


63


5

Efficacy of dual enkephalinase inhibition in a preclinical migraine model is mediated by activation of peripheral delta opioid receptors.

Authors

Mei HR, Hu YY, Kapadia S, Ouimet T, Poras H, Dussor G

Abstract

The aim of this study was to evaluate whether elevating levels of enkephalin by inhibiting their degradation can attenuate stress-induced migraine-like behaviors in mice.