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Papers of the Week

Papers: 15 Jun 2024 - 21 Jun 2024

2024 Jun 14

Drugs R D


Efficacy of Co-Crystal of Tramadol-Celecoxib (CTC) in Patients with Acute Moderate-to-Severe Pain: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials.


Langford R, Viscusi ER, Morte A, Cebrecos J, Sust M, Giménez-Arnau JM, de Leon-Casasola O


New acute pain medications are needed that provide effective analgesia while minimizing side effects and opioid exposure. Clinical trials of co-crystal of tramadol-celecoxib (CTC) have demonstrated an improved benefit/risk profile versus tramadol or celecoxib alone. We pooled data from two phase 3 clinical trials to evaluate the efficacy of CTC 200 mg twice daily (BID) in acute moderate-to-severe pain.