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Papers of the Week
Effects of GDF6 on active protein synthesis by cells of degenerated intervertebral disc.
Authors
Tam V, Chopra N, Sima S, Chen P, Sharma R, Chan D, Diwan AAbstract
Intervertebral disc degeneration (IVD) is a leading cause of low back pain, a prevalent musculoskeletal condition. IVD degeneration is characterized by the degradation of nucleus pulposus (NP), annulus fibrosus (AF), and cartilage endplates (EP). Growth Differentiation Factor 6 (GDF6), part of the bone morphogenetic protein family, has demonstrated potential in maintaining disc integrity. However, its precise role in cellular protein synthesis during IVD degeneration remains unclear.