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Papers of the Week
Effects of caffeine on intracranial pressure and pain perception in freely moving rats.
Authors
Israelsen IME, Westgate CSJ, Kamp-Jensen C, Jensen RH, Eftekhari SAbstract
Caffeine, a non-selective adenosine receptor (AR) antagonist, is the most consumed psychostimulant in the world. Caffeine has been suggested to regulate cerebrospinal fluid secretion and is known both to alleviate and to trigger headache; however, its effect on the regulation of intracranial pressure (ICP) is not known. Therefore, we aimed to investigate the effects of caffeine on ICP and nociceptive responses.