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Papers of the Week

Papers: 15 Apr 2023 - 21 Apr 2023


Animal Studies, Genetics, Molecular/Cellular, Neurobiology, Neuromodulation

Musculoskeletal Pain, Neuropathic Pain

2023 Apr 17

Pain Pract


Effect of stimulation intensity of a differential target multiplexed SCS program in an animal model of neuropathic pain.


Cedeño DL, Kelley CA, Vallejo R


Spinal cord stimulation (SCS) has been proven to be an effective treatment for patients suffering from intractable chronic neuropathic pain. Recent advances in the field include the utilization of programs that multiplex various signals to target different neural structures in the dorsal spinal cord associated with the painful area. Preclinical studies have been fundamental in understanding the mechanism by which this differential target multiplexed programming (DTMP) SCS approach works. Transcriptomic- and proteomic-based studies demonstrated that DTMP can modulate expression levels of genes and proteins involved in pain-related processes that have been affected by a neuropathic pain model. This work studied the effect of the intensity of DTMP signals on mechanical hypersensitivity and cell-specific transcriptomes.