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Papers of the Week

Papers: 27 May 2023 - 2 Jun 2023

Basic Science, Psychology

Animal Studies, Neurobiology

Inflammation/Inflammatory, Orofacial/Head Pain

2023 May 27

Eur J Oral Sci


Effect of sound-induced repeated stress on the development of pain and inflammation in the temporomandibular joint of female and male rats.


Zanelatto FB, Vieira WF, Nishijima CM, Sartori CR, Parada CA, Tambeli CH


Temporomandibular disorder (TMD) is a common painful condition of the temporomandibular joint (TMJ) and associated structures. Stress is a significant risk factor for developing this painful condition that predominantly affects women. This study aimed to test the hypothesis that stress increases the risk of developing TMJ pain by facilitating inflammatory mechanisms in female and male rats. To test this hypothesis, we evaluated TMJ carrageenan-induced expression of pro-inflammatory cytokines and migration of inflammatory cells and TMJ formalin-induced nociception in female and male rats submitted to a repeated stress protocol induced by sound. We found that sound-induced repeated stress facilitates TMJ inflammation and contributes to TMJ nociception development equally in females and males. We conclude that stress is a risk factor for developing painful TMJ conditions in males and females, at least in part, by favoring the inflammatory process similarly in both sexes.