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Papers of the Week

Papers: 4 May 2024 - 10 May 2024

2024 May 09

BMC Biotechnol




ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment.


Shah DK, Ghosh S, More N, Choppadandi M, Sinha M, Srivalliputtur SB, Velayutham R, Kapusetti G


Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and it leads to irreversible inflammation in intra-articular joints. Current treatment approaches for RA include non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), corticosteroids, and biological agents. To overcome the drug-associated toxicity of conventional therapy and transdermal tissue barrier, an injectable NSAID-loaded hydrogel system was developed and explored its efficacy.