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Papers of the Week
Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis.
Authors
Shiraishi T, Ikeda M, Watanabe T, Negishi Y, Ichikawa G, Kaseki H, Akira S, Morita R, Suzuki SAbstract
In women of reproductive age, endometriosis may contribute to dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, adenomyosis, and endometrial ovarian cyst (EOC). Recent studies have shown that chronic inflammation occurs in the pelvis of endometriosis patients and that this inflammation is exacerbated by immunosuppression, leading to survival endometrial debris. However, the detailed immunological mechanisms underlying the aggravation of inflammation and immunosuppression in endometriosis patients remain unclear.