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Papers of the Week
Dorsal root ganglia CSF1 neuronal subtypes have different impact on macrophages and microglia after spared nerve injury.
Authors
Grosu AV, Gheorghe RO, Filippi A, Deftu AF, Isler M, Suter M, Ristoiu VAbstract
Colony-stimulating factor 1 (CSF1) is a growth factor secreted by dorsal root ganglia (DRG) neurons important for DRG macrophages and spinal cord (SC) microglia injury-induced proliferation and activation, specifically released after spared nerve injury (SNI). In this study, we investigated if SNI-induced CSF1 expression and perineuronal rings of macrophages around mouse DRG neurons vary between L3-L5 DRG and with the neuronal type, and if the CSF1 neuronal projections at the SC dorsal horns were associated with an increased microglial number in the corresponding laminae.