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Papers of the Week
Dock4 contributes to neuropathic pain by regulating spinal synaptic plasticity in mice.
Authors
Fu Q, Li H, Zhu Z, Li W, Ruan Z, Chang R, Wei H, Xu X, Xu X, Wu YAbstract
Neuropathic pain (NP) conditions arising from injuries to the nervous system due to trauma, disease, or neurotoxins are chronic, severe, debilitating, and exceedingly difficult to treat. However, the mechanisms of NP are not yet clear. Here we explored the role of Dock4, an atypical Rac1 GEF, in the development of NP.