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Papers of the Week


Papers: 8 Feb 2025 - 14 Feb 2025


2025 Feb 06


BMC Med Res Methodol


39915715


25


1

Discrepancies in safety reporting for chronic back pain clinical trials: an observational study from ClinicalTrials.gov and publications.

Authors

Boyne N, Duke A, Rea J, Khan A, Young A, Van Vleet J, Vassar M

Abstract

Chronic back pain (CBP) is a leading cause of disability worldwide and is commonly managed with pharmacological, non-pharmacological, and procedural interventions. However, adverse event (AE) reporting for these therapies often lacks transparency, raising concerns about the accuracy of safety data. This study aimed to quantify inconsistencies in AE reporting between ClinicalTrials.gov and corresponding randomized controlled trial (RCT) publications, emphasizing the importance of comprehensive safety reporting to improve clinical decision-making and patient care.