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Papers of the Week


Papers: 12 Oct 2024 - 18 Oct 2024


2024 Oct 10


J Headache Pain


39390360


25


1

Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications.

Authors

de Vries T, Schutter D, van den Bogaerdt A, Vincent A, Dammers R, Danser AHJ, MaassenVanDenBrink A

Abstract

Different responses in human coronary arteries (HCA) and human middle meningeal arteries (HMMA) were observed for some of the novel CGRP receptor antagonists, the gepants, for inhibiting CGRP-induced relaxation. These differences could be explained by the presence of different receptor populations in the two vascular beds. Here, we aim to elucidate which receptors are involved in the relaxation to calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin 2 (AM2) in HCA and HMMA.