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Papers of the Week
Differential DNA methylation profiles of Alzheimer’s disease-related genomic pathways in the blood of cognitively-intact individuals with and without high impact chronic pain.
Authors
Strath LJ, Meng L, Zhang Y, Rani A, Huo Z, Foster TC, Fillingim RB, Cruz-Almeida YAbstract
Chronic pain and Alzheimer’s disease (AD) are prevalent in older age and their etiologies remain to be understoodand evidence supports potential associations between the two. Both high impact pain and AD have been previously associated with differences in the epigenome. Interactions with the epigenome may serve as a possible underlying mechanism linking high impact pain and AD.