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Papers of the Week


Papers: 15 Jul 2023 - 21 Jul 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Neurobiology, Pharmacology/Drug Development

PAIN TYPE:
Inflammation/Inflammatory, Itch


2023 Jul 13


J Allergy Clin Immunol


37453613

Difelikefalin suppresses itch and reduces scratching independent of inflammation in a murine model of atopic dermatitis.

Authors

Tamari M, Zamidar L, Ver Heul AM, Nograles K, Goncalves J, Guttman-Yassky E, Lebwohl M, Kim BS

Abstract

Therapies specifically targeting non-histaminergic pruritus are largely lacking. Difelikefalin (DFK) has been found to reduce itch in various chronic pruritic conditions, including atopic dermatitis (AD).