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Papers of the Week
Descending Control of Nociception (DCN) poorly predicts the development of persistent postsurgical pain-like behavior in consomic Dahl S rat strains.
Authors
Ferrari LF, Wilkinson A, Cahoon C, Ramirez A, Rey C, Donaldson GW, Taylor NEAbstract
Chronic postsurgical pain (CPSP) is a poorly recognized outcome of surgery where patients experience pain long after healing from the surgical insult. Descending Control of Nociception (DCN), a phenomenon whereby application of a strong nociceptive stimulus to one part of the body of animals inhibits pain in remote body regions, offers one strategy to identify a propensity to develop CPSP-like behavior. Here we used a consomic rat panel to test the hypothesis that pain persistence is mechanistically linked to ineffective DCN.