I am a
Home I AM A Search Login

Papers of the Week

Papers: 9 Sep 2023 - 15 Sep 2023

Basic Science

Animal Studies, Pharmacology/Drug Development

Neuropathic Pain

2023 Sep 08

Bioorg Med Chem Lett


DDD-028: A Potent, Neuroprotective, Non-Opioid Compound for the Treatment of Diabetic Neuropathy.


Micheli L, Rajamoni J, Di Cesare Mannelli L, Rajagopalan P, Ghelardini C, Rajagopalan R


Diabetic neuropathy (DN) is a painful, chronic ailment that affects a large segment of diabetic population worldwide. Current medications such as pregabalin or duloxetine treat only the pain symptom associated with DN, but not the underlying nerve damage. DDD-028 (1) is a small molecule that displays potent pain-relieving activity in streptozotocin (STZ)-induced rodent model of DN. Combined with other studies indicating that DDD-028 suppresses astrogliosis and nerve damage induced by the anti-cancer drug, paclitaxel, the present study suggests that DDD-028 would be useful as a disease modifying therapeutic in the treatment of DN. The 3-dimensional structure of DDD-028 was confirmed by single crystal X-ray crystallography.